产品货号：
Z22712
中文名称：
ORP150/HYOU1抗体
英文名称：
Anti-ORP150/HYOU1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ORP150/HYOU1 Antibody |
| 指标别名 | GRP170;ORP150;HYOU1;GRP-170;ORP-150 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,ELISA |
| 基因名称 | HYOU1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human ORP150/HYOU1 recombinant protein (Position:K46-K913). |
| 实际分子量 | 150KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Hypoxia up-regulated protein 1 is a protein that in humans is encoded by the HYOU1 gene.The protein encoded by this gene belongs to the heat shock protein 70 family.This gene uses alternative transcription start sites.A cis-acting segment found in the 5' UTR is involved in stress-dependent induction,resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions.The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER.Since suppression of the protein is associated with accelerated apoptosis,it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation.This protein has been shown to be up-regulated in tumors,especially in breast tumors,and thus it is associated with tumor invasiveness.This gene also has an alternative translation initiation site,resulting in a protein that lacks the N-terminal signal peptide.This signal peptide-lacking protein,which is only 3 amino acids shorter than the mature protein in the ER,is thought to have a housekeeping function in the cytosol.In rat,this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal.Alternative splicing results in multiple transcript variants. |
| Uniprot ID | Q9Y4L1 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | hypoxia up-regulated 1 |
| 蛋白名全称 | Hypoxia up-regulated protein 1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 ELISA 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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